'Walk again' drugs to be tested on people

摘要

Two antibodies that enabled the severed spinal nerves of rats to be regenerated are to be tested in humans. The antibodies have helped rats with damaged spinal cords to walk again, by blocking the action of Nogo, a protein that stops nerve cells sprouting new connections. But there were concerns about whether blocking Nogo would lead to uncontrolled neuronal rewiring in the brain or spinal cord and it was also unclear how such a therapy could be given to humans.