High-dose Bosentan in the Prevention and Treatment of Subarachnoid Hemorrhage-induced Cerebral Vasospasm: An Open-label Feasibility Study

Raul G. Nogueira; Michael J. Bodock; Walter J. Koroshetz; Mehmet A. Topcuoglu; Bob S. Carter; Christopher S. Ogilvy; Johnny C. Pryor; Ferdinando S. Buonanno

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High-dose Bosentan in the Prevention and Treatment of Subarachnoid Hemorrhage-induced Cerebral Vasospasm: An Open-label Feasibility Study

机译：大剂量波生坦预防和治疗蛛网膜下腔出血致脑血管痉挛：一项开放性可行性研究

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摘要

To evaluate the safety of high-dosages of the endothelin ETA/B receptor antagonist bosentan in SAH patients at high-vasospasm risk.

机译：为了评估高剂量血管痉挛风险的SAH患者高剂量内皮素ETA / B 受体拮抗剂波生坦的安全性。

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来源
《Neurocritical Care》 |2007年第3期|194-202|共9页
作者
Raul G. Nogueira; Michael J. Bodock; Walter J. Koroshetz; Mehmet A. Topcuoglu; Bob S. Carter; Christopher S. Ogilvy; Johnny C. Pryor; Ferdinando S. Buonanno;
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作者单位

Neurocritical Care and Vascular Neurology Department of Neurology Massachusetts General Hospital Harvard Medical School Boston MA USA;

Department of Pharmacy Massachusetts General Hospital Harvard Medical School Boston MA USA;

Neurocritical Care and Vascular Neurology Department of Neurology Massachusetts General Hospital Harvard Medical School Boston MA USA;

Neurocritical Care and Vascular Neurology Department of Neurology Massachusetts General Hospital Harvard Medical School Boston MA USA;

Cerebrovascular Surgery Neurosurgical Service Massachusetts General Hospital Harvard Medical School Boston MA USA;

Cerebrovascular Surgery Neurosurgical Service Massachusetts General Hospital Harvard Medical School Boston MA USA;

Endovascular Neurosurgery/Interventional Neuroradiology Neurosurgical Service and Department of Radiology Massachusetts General Hospital Harvard Medical School GRB-2-241 55 Fruit St. Boston MA 02114 USA;

Neurocritical Care and Vascular Neurology Department of Neurology Massachusetts General Hospital Harvard Medical School Boston MA USA;

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原文格式 PDF
正文语种 eng
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关键词
Bosentan; Endothelin; Antagonist; Subarachnoid hemorrhage; Vasospasm;

机译：波生坦;内皮素;拮抗剂;蛛网膜下腔出血;血管痉挛;

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1. Brain tissue oxygen monitoring to assess reperfusion after intra-arterial treatment of aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm: A retrospective study [J] . DeshaiesE.M., JacobsenW., SinglaA., AJNR. American journal of neuroradiology . 2012,第7期

机译：动脉内蛛网膜下腔出血引起的脑血管痉挛的动脉内治疗后脑组织氧监测以评估再灌注：一项回顾性研究
2. Endothelin and subarachnoid hemorrhage-induced cerebral vasospasm: pathogenesis and treatment. [J] . Lin CL, Jeng AY, Howng SL, Current medicinal chemistry . 2004,第13期

机译：内皮素和蛛网膜下腔出血引起的脑血管痉挛：发病机理和治疗方法。
3. Endothelin and Subarachnoid Hemorrhage-Induced Cerebral Vasospasm: Pathogenesis and Treatment [J] . Chih-Lung Lin Arco Y. Jeng Shen-Long Howng Aij-Lie Kwan Current Medicinal Chemistry . 2004,第13期

机译：内皮素和蛛网膜下腔出血引起的脑血管痉挛：发病机理和治疗。
4. Section on Cerebrovascular Surgery: Galbraith Award: Endothelial Nitric Oxide Synthase (eNOS) and Heme Oxygenase-1 (HO-1) Gene Polymorphisms Predict Susceptibility to Aneurysmal Subarachnoid Hemorrhage (SAH) and Post-SAH Cerebral Vasospasm [C] . Vini G. Khurana, Youvraj R. Sohni, Wells I. Mangrum Congress of Neurological Surgeons . 2004

机译：关于脑血管外科的部分：GALBraith奖：内皮一氧化氮合酶（ENOS）和血红素氧酶-1（HO-1）基因多态性预测动脉瘤蛛网膜下腔（SAH）和后脑血管痉挛的易感性
5. Cerebrospinal fluid calcium, apoE protein and genotype in individuals with and without cerebral vasospasm after subarachnoid hemorrhage. [D] . Alexander, Sheila Ann. 2004

机译：蛛网膜下腔出血后有和没有脑血管痉挛的个体的脑脊液钙，apoE蛋白和基因型。
6. Safety and Feasibility of Intra-Arterial Nicardipine for the Treatment of Subarachnoid Hemorrhage-Associated Vasospasm: Initial Clinical Experience with High-Dose Infusions [O] . J.G. Tejada, R.A. Taylor, M.S. Ugurel, 2007

机译：动脉内尼卡丁治疗蛛网膜下腔相关血管痉挛的安全性和可行性：高剂量输注的初始临床经验
7. Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit [O] . 2013

机译：蛛网膜下腔出血后他汀和法舒地尔联合治疗抑制Rho / Rho激酶途径并预防脑血管痉挛

High-dose Bosentan in the Prevention and Treatment of Subarachnoid Hemorrhage-induced Cerebral Vasospasm: An Open-label Feasibility Study

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