Expression of cell proliferation markers in pituitary adenomas – correlation and clinical relevance of MIB-1 and anti-topoisomerase-IIα

摘要

Pituitary adenomas represent an inhomogenous tumor entity in terms of growth rate, invasiveness and recurrence. To improve understanding of their different biological behaviour, tumor cell proliferation markers are applied. The aim of this study was to assess proliferation rates overall and in clinico-pathological subgroups using MIB-1 and the recently introduced cell proliferation marker anti-topoisomerase-IIα (Topo-IIα). Further, we correlated the two markers, and defined the clinical value of Topo-IIα in pituitary adenomas as compared to MIB-1.