Association of p53 tumor suppressor gene with paraclinical and clinical modalities of gliomas patients in Malaysia

摘要

Background. Alteration of the tumor suppressor gene p53 is considered to be a critical step in the development of human cancer. Changes in this gene have been detected in a wide range of human tumours, including gliomas. In glioma, the presence of p53 gene alterations has been associated with worse prognosis.