Microglia: a novel treatment target in gliomas

摘要

Microglial cells have not received much attention in neuro-oncology over the past decades, despite the fact that they may be the most abundant cell in glioma tissue. Accordingly, Neuro-Oncology has now devoted a major review article to the changing concepts of what microglial cells do or do not do, both in the normal and diseased brain, with a focus on the biology of gliomas (1). Traditionally, microglial cells have been considered part of the immune system, but to what extent these cells are capable of antigen presentation and participation in immune responses has remained controversial.