CMV infection and glioma, a highly controversial concept struggling in the clinical arena

摘要

Human cytomegalovirus (CMV), a member of the herpes virus family, persists after a usually unrecognized infection lifelong in the body. The sero-prevalence ranges from 50% up to more than 90% of the population. CMV is the most frequent opportunistic CNS infection in severely immunocompromised patients. Postmortem CMV nucleic acid can be detected in the CNS of more than 20% of individuals without CNS diseases, confirming tropism of CMV to CNS cells and indicating that CMV may persist in the CNS lifelong without causing (obvious) harm.