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O-(2-F-18-fluoroethyl)-L-tyrosine PET for evaluation of brain metastasis recurrence after radiotherapy: an effectiveness and cost-effectiveness analysis

机译：O-（2-F-18-氟乙基）-L-酪氨酸PET评估放疗后脑转移的复发：有效性和成本效益分析

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摘要

Background. Conventional MRI is the standard method to diagnose recurrence of brain metastases after radiation. However, following radiation therapy, reactive transient blood-brain barrier alterations with consecutive contrast enhancement can mimic brain metastasis recurrence. Recent studies have suggested that O-(2-F-18-fluoroethyl)-Ltyrosine (FET) PET improves the correct differentiation of brain metastasis recurrence from radiation injury. Based on published evidence and clinical expert opinion, we analyzed effectiveness and cost-effectiveness of the use of FET PET in addition to MRI compared with MRI alone for the diagnosis of recurrent brain metastases.
机译：背景。常规MRI是诊断放射线后脑转移复发的标准方法。然而，放射治疗后，反应性短暂性血脑屏障改变和连续的造影剂增强可以模拟脑转移的复发。最近的研究表明，O-（2-F-18-氟乙基）-酪氨酸（FET）PET可以改善放射损伤引起的脑转移复发的正确分化。基于已发表的证据和临床专家的意见，我们分析了将FET PET和MRI相比单独使用MRI进行MRI的有效性和成本效益，以诊断复发性脑转移。

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  • 来源
    《Neuro-Oncology》 |2017年第9期|1271-1278|共8页
  • 作者

    Heinzel Alexander; Mueller Dirk; Yekta-Michael Sareh Said; Ceccon Garry; Langen Karl-Josef; Mottaghy Felix M.; Wiesmann Martin; Kocher Martin; Hattingen Elke; Galldiks Norbert;

  • 作者单位

    Univ Aachen, Dept Nucl Med, Pauwelsstr 30, D-52074 Aachen, Germany|Res Ctr Juelich, Inst Neurosci & Med, Julich, Germany;

    Univ Cologne, Inst Hlth Econ & Clin Epidemiol, Cologne, Germany;

    Univ Aachen, Dept Conservat Dent Periodontol & Prevent Dent, Aachen, Germany;

    Univ Cologne, Dept Neurol, Cologne, Germany;

    Univ Aachen, Dept Nucl Med, Pauwelsstr 30, D-52074 Aachen, Germany|Res Ctr Juelich, Inst Neurosci & Med, Julich, Germany;

    Univ Aachen, Dept Nucl Med, Pauwelsstr 30, D-52074 Aachen, Germany;

    Univ Aachen, Dept Neuroradiol, Aachen, Germany;

    Univ Cologne, Dept Radiat Oncol, Cologne, Germany|Univ Cologne, Ctr Integrated Oncol, Cologne, Germany|Univ Bonn, Ctr Integrated Oncol, Bonn, Germany;

    Univ Bonn, Dept Radiol, Bonn, Germany|Univ Cologne, Ctr Integrated Oncol, Cologne, Germany|Univ Bonn, Ctr Integrated Oncol, Bonn, Germany;

    Univ Cologne, Dept Neurol, Cologne, Germany|Res Ctr Juelich, Inst Neurosci & Med, Julich, Germany|Univ Cologne, Ctr Integrated Oncol, Cologne, Germany|Univ Bonn, Ctr Integrated Oncol, Bonn, Germany;

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  • 正文语种 eng
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  • 关键词

    F-18-FET PET; cost-effectiveness analysis; decision tree model; recurrent brain metastases;

    机译：F-18-FET PET;成本-效果分析;决策树模型;复发性脑转移;

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