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首页> 外文期刊>Neuro-Oncology >Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors
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Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors

机译：基于临床外显子组的靶向测序与全基因组拷贝数分析相结合：203例小儿脑肿瘤的精确医学分析

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摘要

Background. Clinical genomics platforms are needed to identify targetable alterations, but implementation of these technologies and best practices in routine clinical pediatric oncology practice are not yet well established.
机译：背景。需要临床基因组学平台来确定可靶向的改变，但是在常规临床儿科肿瘤学实践中还没有很好地实现这些技术和最佳实践。

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  • 来源
    《Neuro-Oncology》 |2017年第7期|986-996|共11页
  • 作者

    Ramkissoon Shakti H.; Bandopadhayay Pratiti; Hwang Jaeho; Ramkissoon Lori A.; Greenwald Noah F.; Schumacher Steven E.; ORourke Ryan; Pinches Nathan; Ho Patricia; Malkin Hayley; Sinai Claire; Filbin Mariella; Plant Ashley; Bi Wenya Linda; Chang Michael S.; Yang Edward; Wright Karen D.; Manley Peter E.; Ducar Matthew; Alexandrescu Sanda; Lidov Hart; Delalle Ivana; Goumnerova Liliana C.; Church Alanna J.; Janeway Katherine A.; Harris Marian H.; MacConaill Laura E.; Folkerth Rebecca D.; Lindeman Neal I.; Stiles Charles D.; Kieran Mark W.; Ligon Azra H.; Santagata Sandro; Dubuc Adrian M.; Chi Susan N.; Beroukhim Rameen; Ligon Keith L.;

  • 作者单位

    Dana Farber Canc Inst, Oncol Pathol, Boston, MA 02115 USA|Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Harvard Med Sch, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Oncol Pathol, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA|Brigham & Womens Hosp, Dept Neurosurg, 75 Francis St, Boston, MA 02115 USA;

    Broad Inst MIT & Harvard, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA|Brigham & Womens Hosp, Dept Neurosurg, 75 Francis St, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dept Radiol, Boston, MA USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Ctr Canc Genome Discovery, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA|Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA|Boston Childrens Hosp, Dept Neurosurg, Boston, MA USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Ctr Canc Genome Discovery, Boston, MA 02115 USA|Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA|Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA|Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA|Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA|Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA|Broad Inst MIT & Harvard, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA|Dana Farber Canc Inst, Oncol Pathol, Boston, MA 02115 USA|Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA|Broad Inst MIT & Harvard, Boston, MA 02115 USA|Harvard Med Sch, Boston, MA 02115 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    array CGH; brain tumor; clinical sequencing; pediatric neuro-oncology; precision medicine;

    机译：阵列CGH;脑肿瘤;临床测序;小儿神经肿瘤;精密医学;

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