microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis

Bhere Deepak; Tamura Kaoru; Wakimoto Hiroaki; Choi Sung Hugh; Purow Benjamin; Debatisse Jeremy; Shah Khalid

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microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis

机译：microRNA-7上调死亡受体5并引发抗caspase介导的细胞凋亡的脑肿瘤

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MicroRNAs (miRs) are known to play a pivotal role in tumorigenesis, controlling cell proliferation and apoptosis. In this study, we investigated the potential of miR-7 to prime resistant tumor cells to apoptosis in glioblastoma (GBM).

机译：已知MicroRNA（miR）在肿瘤发生，控制细胞增殖和凋亡中起关键作用。在这项研究中，我们研究了miR-7对胶质母细胞瘤（GBM）中的抗肿瘤细胞凋亡的潜在作用。

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来源
《Neuro-Oncology》 |2018年第2期|215-224|共10页
作者
Bhere Deepak; Tamura Kaoru; Wakimoto Hiroaki; Choi Sung Hugh; Purow Benjamin; Debatisse Jeremy; Shah Khalid;
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作者单位

Harvard Med Sch, Ctr Stem Cell Therapeut & Imaging, Boston, MA USA;

Harvard Med Sch, Ctr Stem Cell Therapeut & Imaging, Boston, MA USA;

Harvard Med Sch, Ctr Stem Cell Therapeut & Imaging, Boston, MA USA;

Harvard Med Sch, Ctr Stem Cell Therapeut & Imaging, Boston, MA USA;

Univ Virginia, Dept Neurol, Charlottesville, VA USA;

Harvard Med Sch, Ctr Stem Cell Therapeut & Imaging, Boston, MA USA;

Harvard Med Sch, Ctr Stem Cell Therapeut & Imaging, Boston, MA USA;

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正文语种 eng
中图分类
关键词
glioblastoma; stem cell therapy; microRNA; cancer; death receptor; apoptosis;

机译：胶质母细胞瘤;干细胞治疗;microRNA;癌症;死亡受体;细胞凋亡;

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专利

1. Wild-type measles virus infection upregulates poliovirus receptor-related 4 and causes apoptosis in brain endothelial cells by induction of tumor necrosis factor-related apoptosis-inducing ligand [J] . AbdullahH., BrankinB., BradyC., Journal of Neuropathology and Experimental Neurology: Official Journal of the American Association of Neuropathologists, Inc . 2013,第7期

机译：野生型麻疹病毒感染通过诱导肿瘤坏死因子相关的凋亡诱导配体诱导上调脊髓灰质炎病毒受体相关4并引起脑内皮细胞凋亡
2. NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5 [J] . Kimberly A. Foster, Esther P. Jane, Daniel R. Premkumar, International journal of oncology . 2015,第2期

机译：NVP-BKM120通过上调Noxa和死亡受体5来增强肿瘤坏死因子相关的凋亡诱导配体耐药神经胶质瘤细胞系的凋亡5
3. Histone deacetylase inhibitors upregulate death receptor 5|[sol]|TRAIL-R2 and sensitize apoptosis induced by TRAIL|[sol]|APO2-L in human malignant tumor cells [J] . Susumu Nakata, Tatsushi Yoshida, Mano Horinaka, Oncogene . 2004,第37期

机译：组蛋白脱乙酰基酶抑制剂上调人恶性肿瘤细胞中的死亡受体5 | [sol] | TRAIL-R2并敏化TRAIL | [sol] | APO2-L诱导的凋亡
4. Apoptosis and receptor-mediated signal regulation of cultured tumors by glycoprotein from Meretrix lusoria [C] . Zwe-Ling Kong, Chau-Chi Hwang, Chen-Wei Lai Annual Meeting of the Japanese Association for Animal Cell Technology . 2002

机译：来自Meretrix Lusoria的糖蛋白培养肿瘤的凋亡和受体介导的信号调节
5. Involvement of TRAIL death receptors in human tumorigenesis and mechanisms of TRAIL-induced apoptosis signaling. [D] . Ozoren, Nesrin. 2002

机译：TRAIL死亡受体参与人类肿瘤发生和TRAIL诱导的细胞凋亡信号传导机制。
6. microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis [O] . Deepak Bhere, Kaoru Tamura, Hiroaki Wakimoto, 2018

机译：microRNA-7上调死亡受体5并引发抗caspase介导的细胞凋亡的脑肿瘤
7. Wild-type Measles Virus Infection Upregulates Poliovirus Receptor-Related 4 and Causes Apoptosis in Brain Endothelial Cells by Induction of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand [O] . Abdullah, Hani'ah, Brankin, Brenda, Brady, Clare, 2013

机译：野生型麻疹病毒感染上调脊髓灰质炎病毒受体相关的4，并通过诱导肿瘤坏死因子相关的凋亡诱导配体诱导脑血管内皮细胞凋亡。

microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis

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