Association of MEGSIN 2093C–2180T haplotype at the 3′ untranslated region with disease severity and progression of IgA nephropathy

摘要

Background.MEGSIN is a gene predominantly expressed in the renal mesangium, and is upregulated in IgA nephropathy (IgAN). Our previous study has shown that the 2093C and 2180T alleles at the 3′ untranslated region (3′UTR) of the gene are associated with susceptibility to IgAN, but the relationships of these genetic variants with the clinical manifestations and renal histological lesions of IgAN have not been examined previously.