High prevalence of renal dysfunction in children after liver transplantation: non-invasive diagnosis using a cystatin C-basedn equation

摘要

Background. Chronic kidney disease (CKD) has been increasingly shown to be a negative prognostic factor after liver transplantation (Ltx). Creatinine-based glomerular filtration rate (GFR) formulas are notoriously insensitive. In children, non-invasive determination of GFR by measurement of serum cystatin C is feasible and repeatedly correlated to the gold standards of GFR measurements. The aim of our study was to determine GFR using cystatin C (GFR_(cys)) in comparison with conventional calculated creatinine clearance (GFR_(crea)) in the long-term follow-up after paediatric liver transplantation (pLtx) in a large number of patients.