Insights into Wnt binding and

摘要

Members of the frizzled family of seven-pass transmembrane proteins serve as receptors for Wnt signalling proteins. Wnt proteins have important roles in he differentiation and pattern- ing of diverse tissues during animal development, and nap- propriate activation of Wnt signalling pathways is a key feature of many cancers. An extracelular cysteine-rich domain (CRD) at the amino terminus of Frizzld proteins binds Wnt proteins, as do homologous domains n soluble proteins-termed secreted Frizzled-related proteins-that function as antagonists of Wnt Signalling.