Mice share yeast's ageing system

摘要

A protein that regulates lifespan in yeast by protecting its genome may perform the same function in mammals, studies in mice suggest. The work addresses a lingering uncertainty about sirtuins, a family of proteins that are a focus of research in the lucrative market for anti-ageing drugs. In April, Sirtris Pharmaceuticals, based in Cambridge, Massachusetts, and co-founded by David Sinclair of Harvard Medical School, who is the lead author of the new work, was purchased by pharmaceuti-cal giant GlaxoSmithKline for US$720 million.