CASE STUDY

摘要

Chloroaniline The summary dossier on 2-chloroaniline, an aromatic amine used to manufacture pesticides and Pharmaceuticals, reports toxicity data that it describes as "conclusive", but says that they are "not sufficient" to classify the substance as toxic to reproduction. It also says that data are "lacking" on whether toxic effects can be passed on to offspring through the mother's milk. Yet the summary suggests that children of fathers exposed to aromatic amines before conception are at higher risk of brain tumours (J. R. Wilkins and T. Sinks Am. J. Epidemiol. 132, 275-292; 1990). It also cites what Costanza Rovida, a consultant chemist in Varese, Italy, describes as a "robust" (but unpublished) study showing that the substance caused malformations in rats. The summary dossier does not suggest new tests to investigate 2-chloroaniline. N.G.