Stem-cell model of premature ageing

摘要

The rare disorder Hutchinson-Gilford progeria syndrome (HGPS) is characterized by the premature onset of signs associated with normal ageing, such as atherosclerosis and the degeneration of vascular smooth muscle cells. Liu et al. report that the altered structure of the nuclear envelope and the epigenetic modifications that accumulate during physiological ageing or under specific disease conditions are restored to normalcy by reprogramming fibroblasts from patients with HGPS as induced pluripotent stem (iPS) cells.