Mediator kinase inhibition further activates super-enhancer-associatedn genes in AML

摘要

Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded with the Mediator complex, transcription factors and chromatin regulators, drive high expression of genes implicated in cell identity and disease, such as lineage-controlling transcription factors and oncogenes(1,2). BRD4 and CDK7 are positive regulators of SE-mediated transcription(3-5). By contrast, negative regulators of SE-associated genes have not been well described. Here we show that the Mediator-assoc