Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae)

摘要

A new colchicinoid from Colchicum crocifolium Boiss. (Colchicaceae) was isolated and identified as N,N-dimethyl-N-deacetyl-(−)-cornigerine (5), along with four known compounds, but new to the species: (−)-colchicine (1), (−)-demecolcine (2), (−)-N-methyl-(−)-demecolcine (3) and 3-demethyl-N-methyl-(−)-demecolcine (4). All isolated compounds showed potent cytotoxicity against a human cancer cell panel.