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首页> 外文期刊>AAPS PharmSciTech >Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention
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Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention

机译:酒石酸美托洛尔作为胃黏膜模型药物的双层浮片的优化

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摘要

The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing metoprolol tartrate (MT) as a model drug by the optimization technique. A 23 factorial design was employed in formulating the GFDDS with total polymer content-to-drug ratio (X1), polymer-to-polymer ratio (X2), and different viscosity grades of hydroxypropyl methyl cellulose (HPMC) (X3) as independent variables. Four dependent variables were considered: percentage of MT release at 8 hours, T50%, diffusion coefficient, and floating time. The main effect and interaction terms were quantitatively evaluated using a mathematical model. The results indicate that X1 and X2 significantly affected the floating time and release properties, but the effect of different viscosity grades of HPMC (K4M and K10M) was nonsignificant. Regression analysis and numerical optimization were performed to identify the best formulation. Fickian release transport was confirmed as the release mechanism from the optimized formulation. The predicted values agreed well with the experimental values, and the results demonstrate the feasibility of the model in the development of GFDDS.
机译:本研究的目的是通过优化技术开发一种优化的胃浮药物输送系统(GFDDS),其中含有酒石酸美托洛尔(MT)作为模型药物。采用23 因子设计设计了GFDDS,其总聚合物含量/药物比(X1 ),聚合物/聚合物比(X2 )和不同粘度等级的羟丙基甲基纤维素(HPMC)(X3 )作为自变量。考虑了四个因变量:8小时MT释放百分比,T50%,扩散系数和漂浮时间。使用数学模型定量评估了主要作用和相互作用项。结果表明,X1 和X2 对漂浮时间和释放性能有显着影响,但不同粘度等级的HPMC(K4M和K10M)的影响并不显着。进行回归分析和数值优化以确定最佳配方。 Fickian释放运输被确认为优化配方的释放机理。预测值与实验值吻合良好,结果证明了该模型在GFDDS开发中的可行性。

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