The objective of the present research was to develop a bi-layer tablet of Metoprolol tartrate using? disintegrant? starch? for the fast release layer and HPMC K grade polymers? for the sustaining layer. In vitro dissolution studies were carried out in an Indian Pharmacopoeia dissolution testing apparatus II (paddle method). The formulations gave an initial burst effect to provide the loading dose of the drug followed by sustained release for 12 h from the sustaining layer of matrix embedded tablets. The In-vitro release study of this tablet indicated sustained release for Metoprolol tartrate and followed zero order release and 95% drug in 24h in vitro and it follow Fickian diffusion.
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