Identification of HHV8 in early Kaposi's sarcoma: implications for Kaposi's sarcoma pathogenesis

摘要

Conclusions-The presence of HHV8 in early lesions supports a role for HHV8 in the pathogenesis of Kaposi's sarcoma. Coupled with recent seroepidemiological Studies, these results suggest that HHV8 is The aetiological agent of Kaposi's sar- Coma. Its precise interaction with other Factors known to be involved in the devel- Opment of Kaposi's sarcoma, including Cytokines and anti-apoptosis genes, re- Quires elucidation. Aims-Kaposi's sarcoma is a vascular Tumour of uncertain pathogenesis possi- Bly caused by an infectious agent, identi- Fied in high risk grous.