An electrochemical sensor for rizatriptan benzoate determination using Fe_3O_4 nanoparticle/multiwall carbon nanotube-modified glassy carbon electrode in real samples

摘要

In this paper a sensitive and selective electrochemical sensor for determination of rizatriptan benzoate (RZB) was proposed. A glassy carbon electrode was modified with nanocomposite of multiwalled carbon nanotubes (MWCNTs) and Fe_3O_4 nanoparticles (Fe_3O_4/MWCNTs/GCE). The results obtained clearly show that the combination of MWCNTs and Fe_3O_4 nanoparticles definitely improves the sensitivity of modified electrode to RZB determination. The morphology and electroanalytical performance of the fabricated sensor were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS), square wave voltammetry (SWV) and cydic voltammetry (CV). Also, the effect of experimental and instrumental parameters on the sensor response was evaluated. The square wave voltammetric response of the electrode to RZB was linear in the range 0.5-100.0 μmol L~(-1) with a detection limit of 0.09 μmol L~(-1) under the optimum conditions. The investigated method showed good stability, reproduc-ibility and repeatability. The proposed sensor was successfully applied for real life samples of blood serum and RZB determination in pharmaceutical.