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首页> 外文期刊>Materials science & engineering >Recovery evaluation of rats' damaged tibias: Implantation of core-shell structured bone scaffolds made using hollow braids and a freeze-thawing process
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Recovery evaluation of rats' damaged tibias: Implantation of core-shell structured bone scaffolds made using hollow braids and a freeze-thawing process

机译：大鼠受损胫骨的恢复评估：使用空心编织物和冷冻-融化工艺植入核壳结构骨支架

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摘要

This study prepares biodegradable bone scaffolds helping the recovery of damaged tibias of rats. Polyvinyl alcohol (PVA) plied yarns are fabricated into hollow braids. The braids are combined with hydroxyapatite (HA)/gelatin/ PVA mixtures and processed using freeze-thawing and freeze-drying processes in order to form bone scaffolds. These bone scaffolds are observed by scanning electron scope (SEM) and tested for compression strength. Afterwards, recovery of damaged bone, the morphology of the bone, and the histological observation are evaluated. Results indicate a small amount of HA helps in enhancing the compressive strength of bone scaffolds. Results of in vivo assay indicate the damaged tibias of rats recover and function well eight weeks after the implantation, and exhibit a normal morphology. Histological observation confirms the bone scaffolds gradually decompose, allowing tissue infiltration and facilitating ossification. This study successfully produces bone scaffolds with satisfactory mechanical properties helping in the recovery of damaged tibias of rats.
机译：这项研究准备了可生物降解的骨骼支架，以帮助恢复受损的胫骨。聚乙烯醇（PVA）合股纱被制成空心编织物。将编织物与羟磷灰石（HA）/明胶/ PVA混合物混合，并使用冻融和冻干工艺进行处理，以形成骨支架。通过扫描电子显微镜（SEM）观察这些骨支架并测试抗压强度。之后，评估受损骨骼的恢复，骨骼的形态以及组织学观察。结果表明少量的HA有助于增强骨支架的抗压强度。体内测定的结果表明，大鼠的受损胫骨在植入后八周后恢复良好并正常运作，并表现出正常的形态。组织学观察证实骨支架逐渐分解，使组织浸润并促进骨化。这项研究成功地生产了具有令人满意的机械性能的骨支架，有助于恢复受损的胫骨。

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  • 来源
    《Materials science & engineering》 |2017年第10期|481-490|共10页
  • 作者

    Jia-Horng Lin; Mong-Chuan Lee; Chih-Kuang Chen; Chien-Lin Huang; Yueh-Sheng Chen; Shih-Peng Wen; Shu-Ting Kuo; Ching-Wen Lou;

  • 作者单位

    Innovation Platform of Intelligent and Energy-Saving Textiles, Tianjin Polytechnic University, Tianjin 300387, China,Laboratory of Fiber Application and Manufacturing, Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan,Department of Chemistry and Chemical Engineering, Minjiang University, Fuzhou 350108, China,School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan,Department of Fashion Design, Asia University, Taichung 41354, Taiwan;

    Graduate Institute of Biotechnology and Biomedical Engineering Central Taiwan University of Science and Technology, Taichung 40601, Taiwan;

    The Polymeric Biomaterials Lab, Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan;

    Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan;

    Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 40402, Taiwan;

    Laboratory of Fiber Application and Manufacturing, Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan;

    Laboratory of Fiber Application and Manufacturing, Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan;

    Department of Chemistry and Chemical Engineering, Minjiang University, Fuzhou 350108, China,Graduate Institute of Biotechnology and Biomedical Engineering Central Taiwan University of Science and Technology, Taichung 40601, Taiwan,School of Textiles, Tianjin Polytechnic University, Tianjin 300387, China;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    Braid; Polyvinyl alcohol (PVA); Hydroxyapatite (HA); Recovery of damaged bone; Bone scaffolds;

    机译：编织;聚乙烯醇（PVA）;羟基磷灰石（HA）;恢复受损的骨头;骨棚架;

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