Electrospun Icariin-Loaded Core-Shell Collagen Polycaprolactone Hydroxyapatite Composite Scaffolds for the Repair of Rabbit Tibia Bone Defects

摘要

Electrospinning is a widely used technology that can produce scaffolds with high porosity and surface area for bone regeneration. However, the small pore sizes in electrospun scaffolds constrain cell growth and tissue-ingrowth. In this study, novel drug-loading core-shell scaffolds were fabricated via electrospinning and freeze drying to facilitate the repair of tibia bone defects in rabbit models.