Synthesis and properties of thermosensitive poly(N-isopropylacrylamide-co-methyl methacrylate) hydrogel with rapid response

摘要

Poly (N-isopropylacrylamide-co-methyl metharylate) (P(NIPA-co-MMA)) hydrogel was synthesized by making use of the phase separation technique in the mixed solvent (distiled water/glacial acetic acid). This hydrogel responds to external temperature changes very quickly owing to its macroporous network structure formed during the copolymerization/cross- linking process. iN this paper, the on-off switch behavior of the P(NIPA-oMMA) hydrogel with different content of hydrophobic component (MMA) was further investigated and proved to be more sensitive. This fast responsive hydrogel with hydrophobic component and improved sensitivity of its on-off switch behavior would have potential applications in the field of drug-controlled release.