Bioactive monolithic composites of silica/polydimethylsiloxane/calcium phosphate obtained at room temperature in sol-gel micromolding technique

摘要

In this work, the novel silica/polydimethylsiloxane/calcium phosphate composites (70%Si20%PDMS10% CaP and 60%Si20%PDMS20%CaP) were prepared in the sol-gel process combined with micromolding technique at room temperature. The self-formation rate of carbonate hydroxyapatite on the composites surface was examined under in vitro biomimetic conditions. Results showed the progressive increase in the surface mineralisation ability for 70%Si20%PDMS10%CaP composite and the retarded initial mineralisation promotion for the 60%Si20%PDMS20%CaP composite. In contrast, model drug release (doxorubicin) form the 60%Si20%PDMS20%CaP was slower compared to 70%Si20%PDMS10%CaP composite. This low temperature sol-gel micromolding process may lead to novel silica/polydimethylsiloxane/calcium phosphate composites with potential application as smart filling scaffolds in bone surgery with the possible loading of drug molecules. (C) 2016 Elsevier B.V. All rights reserved.