Mechanism and Activation Energies in Different Blends of Poly-(ε-caprolactone) with Polyethyleneglycol (PEG) and Polyvinyl Alcohol (PVA)

摘要

In this article we study the calorimetric characterization using different differential and integral kinetic methods with data from differential scanning calorimeter (DSC). The correlation of activation energies obtained using Kissinger and Flynn-Wall-Ozawa integral methods were lower than 0.99, so it was necessary used the Coats-Redfern Method to determinate the activation energies and the mechanism of fluid-crystalline phase transition process. This mechanisms follows nucleation and growth model (sigmoidal A4 type an Avrami 3 mechanism). This study permits to obtain a tool to predict the disorder of the structure for hydrophobic or hydrophilic samples that could be used to the release of the drugs.