Isolation of CYP2L2 and Two other Cytochrome P450 Sequences from a Spiny Lobster, Panulirus argus, Hepatopancreas cDNA Library

摘要

Cytochrome P450 monooxygenases constitute an enzyme superfamily, with at least 74 known families. Members of CYP families 1-4 are important in the phase I metabolism of lipophilic xenobiotics, such as those found in contaminated marine environments. Previous studies (James et al. Arch. Biochem. Biophys. (1996) 329, 31-38) showed that a major form of P450 in spiny lobster, Panu- lirus argus, hepatopancreas was CYP2L1, a new sub-family, and that there was evidence for other P450 forms in hepatopancreas.