The Oral Bioavailability, Pharmacokinetics and Biotransformation of 9-Hydroxybenzo[a]pyrene in the American Lobster, Homarus americanus

摘要

the pharmacokinetics of [~3H]-9-hydroxy-benzo[a]pyrene (9-OH-BaP) were examined after single intrapericardial (IV) or oral doses to intermolt American lobsters, Homarus americanus. A three-compartment model best described the disposition of parent 9-OH-BaP in the hemolymph after IV administration. The major metabolite found in hemolymph 8 h after administration, BaP 9-sulfate, reached its peak concentration at one day after the dose. BaP 9-sulfate, eliminated from hemolymph more rapidly than 9-OH-BaP or BaP9-β-D-gluco- side, which were present in all hemolymph samples at all times.