Tunable Micropatterned Substrates Based on Poly(dopamine) Deposition via Microcontact Printing

摘要

A simple technique was developed to fabricatentunable micropatterned substrates based on mussel-inspirednsurface modification. Polydopamine (PDA) was developed onnpolydimethylsiloxane (PDMS) stamps and was easilynimprinted to several substrates such as glass, silicon, gold,npolystyrene, and poly(ethylene glycol) via microcontactnprinting. The imprinted PDA retained its unique reactivitynand could modulate the chemical properties of micropatternsnvia secondary reactions, which was illustrated in this study.nPDA patterns imprinted onto a cytophobic and nonfoulingnsubstrates were used to form patterns of cells or proteins. PDAnimprints reacted with nucleophilic amines or thiols to conjugate molecules such as poly(ethylene glycol) for creating nonfoulingnarea. Gold nanoparticles were immobilized onto PDA-stamped area. The reductive ability of PDA transformed silver ions tonelemental metals as an electroless process of metallization. This facile and economic technique provides a powerful tool forndevelopment of a functional patterned substrate for various applications.