Effects of Ge Gen Decoction on PGE_2 Content and COX Activity in the Degenarated Cervical Intervertebral Discs of Rats

摘要

After the rat model of cervical spondylosis was developed for 6 months, the PGE_2 content and COX activity in the cervical intervertebral discs were determined respectively by radioimmunoassay and catalytic activity assay. The results indicated that the PGE_2 content and COX activity in the model rat increased significantly, and that Ge Gen Decoction could down-regulate the PGE_2 content and inhibit COX activity. This is possibly one of the mechanisms of Ge Gen Decoction for treating cervical spondylosis.