Aryl nitriles and thioethers are complementary functional groups found in a wide range of biologically active molecules. To access these functional groups, cyanide salts and thiols are often employed-but cyanide salts are toxic, and thiols are both toxic and malodorous. While safer alternatives have been developed for the syntheses of both classes of compounds, they rely on aryl halide electrophiles' irreversible coupling and require distinct catalytic systems.
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