TWO BIRDS, ONE PROBE: SIMULTANEOUS FLUORESCENT DETECTION OF H_2O_2 AND ATP

摘要

Oxidative stress and abnormal energy metabolism are hallmarks of several neurological disorders, including Parkinson's disease and Alzheimer's disease. Measuring the levels of reactive oxygen species and energy sources in the cell enables a better understanding of how oxidative and energetic processes contribute to the progression of these diseases, which may facilitate the development of more effective treatments. However, current methods to detect such analytes require extensive sample preparation and are therefore unable to provide real-time monitoring of concentration changes in response to specific stimuli.