Synthesis and Single-Molecule Studies of a Well-Defined Biomimetic Modular Multidomain Polymer Using a Peptidomimetic β-Sheet Module

摘要

A new class of well-defined modular polymers has been synthesized using a double-closed-loop peptidomimetic β-sheet module. Single-molecule nanomechanical studies on these polymers show more uniform sawtooth patterns, suggesting that the DCL modular polymer undergoes sequential unfolding upon stretching. Further studies toward the bulk mechanical properties and the design of well-defined modules having varying H-binding strength are currently underway in our laboratory.