Decarboxylative Aldol Reactions of Allyl β-Keto Esters via Heterobi metallic Catalysis

摘要

We have developed a mild and selective heterobi-metallic-catalyzed decarboxylative aldol reaction. The reaction is promoted by Pd(0)—and Yb(Ⅲ)—DIOP complexes and involves the in situ formation of a ketone enolate from allyl β-keto esters followed by addition of the enolate to aldehydes. The reaction is a new example of heterobimetallic catalysis in which the optimized reaction conditions require the addition of both metals. Future investigations will focus on expansion of the reaction scope to include other electrophiles.