Self-Assembling Peptide Nanotubes from Enantiomeric Pairs of Cyclic Peptides with Alternating D and L Amino Acid Residues

摘要

During the past 10 years studies aiming at the design and synthesis of molecules that self-assemble into supramolecular structures have received increased attention. A particular attractive system is cyclic peptides composed by an even number of alternating D- and L-amino acid residues. These can self-assemble into extended hollow tubular structures, so-called peptide nanotubes, by forming antiparallel hydrogen bonds between homochiral amino acid residues of adjacent rings.