Rhodium-Catalyzed Carbonylative [3+2+1] Cycloaddition Reaction: Catalytic Formation of Bicyclic Cyclohexenones from Trienes and Carbon Monoxide

摘要

Transition metal-catalyzed cycloaddition reactions are powerful methods for the construction of complex polycyclic systems. Carbonylative coupling, as a tool for the synthesis of cyclic compounds possessing a carbonyl moiety, is especially fascinating. In this respect, the carbonylative alkyne-alkene coupling (Pauson-Khand reaction) has been thoroughly studied. However, no report of carbonylative cycloaddition giving cyclohexenones has been disclosed yet, although cyclohexenones are very useful starting materials in the synthesis of natural products. Recently, lanthanide- and rhodium-catalyzed [4+2] cycloaddition reactions have been used in the synthesis of cyclohexenone derivatives.