Synthesis of the Tetrahydroisoquinoline Alkaloid (±)-Renieramycin G and a (±)-Lemonomycinone Analogue from a Common Intermediate

摘要

A general approach to both mono- and bistetrahy-droisoquinoline alkaloids from a common advanced intermediate has been described. The common intermediate 17 was synthesized from imine 8 in 10 steps and 32% yield. From 17, (±)-lemonomycinone amide (7) was synthesized in nine steps and 16% yield, while (±)-renieramycin G (4) was synthesized in eight steps and 18% yield.