Chemo-enzymatic rapid syntheses of tetrahydroisoquinoline alkaloids

摘要

The anti-tumor tetrahydroisoquinoline (THIQ) alkaloids, represented by jorunnamycin A (1) and saframycins, share common pentacyclic scaffold. We previously elucidated unique biosynthetic mechanism for construction of the pentacyclic scaffold catalyzed by SfmC, a module of NRPS.1