Catalytic Enantioselective Fluorination of Oxindoles

摘要

Introduction of fluorine atoms into bioactive compounds is a common approach to improve the biological activity profile.Therefore,catalytic enantioselective fluorination has attracted growing interest.We recently reported efficient fluorination reactions of beta-ketoesters and beta-ketophosphonates.Several chiral catalysts for enantioselective fluorination have been developed,but in most cases,they were applied only to beta-ketoesters,and other nucleophiles were rarely examined.Therefore,development of novel reactions applicable to other carbonyl compounds is still required.