Destroying Gadofullerene Aggregates by Salt Addition in Aqueous Solution of Gd@C_(60)(OH)_xand Gd@C_(60)[C(COOH_2)]_(10)

摘要

Water-soluble fullerene derivatives possess potential for biomedi-cal applications as antioxidants,anti-HIV drugs,X-ray contrast agents,bone-disorder drugs,and photosensitizers for photody-namic therapy.In addition,endohedral metallofullerenes (M@C_(2n)) have been suggested as nuclear medicines (M = Ho~(3+)),fluorescent tracers (M = Er~(3+)),and MRI contrast agents (M = Gd~(3+)) largely because the closed fullerene cage ensures against toxic metal-ion release in vivo.