High Facial Diastereoselectivity in Intra- and Intermolecular Reactions of Chiral Benzylic Cations

摘要

The facial diastereoselectivity of the nucleophilic addition to alpha-chiral ketones (R = alkyl,aryl) or aldehydes (R = H) of the general structure A (Figure 1) is one of the most extensively studied phenomena in stereoselective organic synthesis.The reaction is characterized by the substrate combination weak electrophile/strong nucleophile.It is opposed at the other end of the reactivity scale by the substrate combination strong electrophile/weak nucleophile.