Photorelease of Carboxylic Acids,Amino Acids,and Phosphates from N-Alkylpicolinium Esters Using Photosensitization by High Wavelength Laser Dyes

摘要

The development of selective bond-breaking reactions that are triggered by the absorption of a photon is a fundamental goal of photochemistry.These reactions also have many practical applications.For example,photolithographic techniques create nanometer-scale images on a surface by selectively breaking bonds in a photoinitiator molecule,creating free radicals or cations.These intermediates,in turn,react in a way to modify the solubility of a photoresist coating.The photochemical generation of free radicals has also been exploited in synthetic chemistry.An additional family of applications utilizes photochemical bond breaking with the goal of releasing stable molecules,rather than reactive intermediates.In synthetic chemistry,such systems are referred to as "photoreleasable protecting groups" (PRPGs),and in biophysical applications they are referred to as "caged molecules" (e.g.,caged ATP or caged neurotransmitters).