Enzymatic Approach to Unnatural Glycosides with Diverse Aglycon Scaffolds Using Glycosyltransferase VinC

摘要

Glycosides consist of a major class of biologically important metabolites,including various types of antibiotics for clinical use.Among the current interests in drug discovery is to develop glycoside libraries with structural and biological diversities.Generally,since both aglycon and the sugar part have to be properly installed in a glycoside to exert its significant biological activity,formation of glycosidic linkage turns out to be a key process for the development of such libraries.Enzymatic synthesis appears to be a method of choice to this end,and it is absolutely necessary to explore potent glycosyltransferases.A key element along this line is the degree of promiscuity of glycosyltransferase toward both glycosyl donor and acceptor.