Organocatalytic Regio- and Asymmetric C-Selective S_Nar Reactions-Stereoselective Synthesis of Optically Active Spiro-pyrrolidone-3,3'-oxoindoles

摘要

The nucleophilic aromatic substitution (S_NAr) reaction is a fundamental transformation in organic chemistry.The nucleophiles employed are mostly amines or phenols,but 1,3-dicarbonyl compounds are reactive enough to be arylated under mild conditions.Although the nucleophilic aromatic substitution reaction has been known for more than 100 years,there are only sporadic examples,restricted to intramolecular reactions and oxygen nucleophiles,in which the stereochemistry of the newly formed center is controlled.