Synthesis and Biological Activity of PTEN-Resistant Analogues of Phosphatidylinositol 3,4,5-Trisphosphate

摘要

The phosphoinositide 3-kinase (PI 3-K) signaling pathway contains important therapeutic targets in human pathophysiology.Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P_3) is a ubiquitous signaling lipid found in higher eukaryotic cells and activates a plethora of downstream cellular processes.These signaling events include cell proliferation and transformation,cell shape and motility,and insulin action and alteration of glucose transport.PtdIns(3,4,5)P_3-regulated signaling is modulated by the lipid 3-phosphatase PTEN and SH_2 domain-containing inositol 5-phos-phatase SHIP.