Key Role of the Lewis Base Position in Asymmetric Bifunctional Catalysis: Design and Evaluation of a New Ligand for Chiral Polymetallic Catalysts

摘要

Our group is involved in developing new asymmetric catalysts based on the concept of bifunctional catalysis.Specifically,we recently clarified the three-dimensional crystal structures of asymmetric catalysts,useful in various cyanation reactions,containing rare earth metals and chiral ligands derived from D-glucose (1 and 2).This previous study demonstrated that the active asymmetric catalyst is a polymetallic complex,and that the higher-order structure of the complex has profound effects on the function (enantioselectivity and activity) of the asymmetric catalyst.In this communication,we report that a subtle change of the chiral ligand structure is amplified in the higher-order structure of the polymetallic complex,resulting in a dramatic difference in the function of the asymmetric catalyst.