Building Addressable Libraries:The Use of a Mass Spectrometry Cleavable Linker for Monitoring Reactions on a Microelectrode Array

摘要

Chip-based molecular arrays are important tools for probing interactions between libraries of potential ligands and biological receptors.Arrays where the members of the library can be individually addressed are particularly intriguing.For example,building a molecular library on an addressable array of microelec-trodes (Figure la)would allow for the "real-time"monitoring of members in the library using the electrodes.But how does one build a molecular library so that its individual members all reside proximal to a unique electrode?In order to answer this question,we have been developing the synthetic methodology needed for site-selectively synthesizing molecules proximal to individual microelectrodes in an addressable array.