In Search of Radical Intermediates in the Reactions Catalyzed by Lysine 2,3-Aminomutase and Lysine 5,6-Aminomutase

摘要

Radical mechanisms offer the adenosylmethionine (AdoMet)-and adenosylcobalamin (AdoCbl)-dependent aminormitases the opportunity to execute very specific 1,2-amino rearrangements between adjacent carbons.Lysine 2,3-aminomutase (2,3-LAM)and lysine 5,6-aminomutase (5,6-LAM)belong to these intriguing classes of enzymes and their activity is closely related as follows.