The Discovery of an Enantioselective Receptor for(-)-Adenosine from a Racemic Dynamic Combinatorial Library

摘要

Dynamic combinatorial chemistry(DCC)has developed into a powerful tool for the amplification and identification of new hosts for a broad range of guests,ultimately yielding such remarkably complex structures as the catenated dodecapeptide receptor for acetylcholine.DCC experiments aimed at the discovery of enantioselective receptors have,however,not been reported,though diastereoselective receptor amplifications are known.