Pd(Ⅱ)-Catalyzed Enantioselective Oxidative Tandem Cyclization Reactions. Synthesis of Indolines through C-N and C-C Bond Formation

摘要

We have developed a Pd(Ⅱ)-catalyzed enantio-selective oxidative tandem cyclization using readily available (—)-sparteine as the chiral ligand and molecular oxygen as a green oxidant. This methodology provides direct access to enantioenriched and structurally versatile indolines. We are currently undertaking mechanistic studies of this oxidative tandem cyclization, and the results will be reported in due course.